Custom Synthesis of modified PEGs
mPEG、mPEG-NH2、mPEG-SS、mPEG-SC、mPEG2-NHS、mPEG-SPA、mPEG-ALD、mPEG-MAL、HO-PEG-COOH、mPEG-b-PS、mPEG-b-PI、mPEG-b-PAN、mPEG-b-PCL、mPEG-b-PMMA、α-hydroxyl-PEG-ω- amide、 mPEG-carboxyl、mPEG- cyan、hyperbranched polyglycerol , etc.
Maleimide(MAL),
NHS este(succinimidyl, SCM, SC, SG-glutarate, SS-succinate),
ortho-Pyridyldisulfide(OPSS),
n-Succinimidyl-3-(2-pyridyldithiol)propionate (SPDP),
Biotin,
Silane,
Nitrophenyl carbonate(NPC),
Amine (NH2, Boc or Fmoc),
Acid (COOH),
Lipid (DSPE),
Aldehyde,
Isocyanate (NCO),
Isothiocyanate (NCS),
Vinylsulfone (VS),
Hydrazide,
Acrylate (acryloyl),
Epoxide,
Succinic and Glutaric acid,
Tosylate and Mesylate
1.mPEG (monomethoxypoly(ethylene glycol)) or mPEO (monomethoxypoly (ethylene oxide))
CH3O-(CH2CH2O)n-CH2CH2OH
mPEG with low diol content, assay of diol <5%, Disperse(PDI):1.04~1.1
Time required : about 2 weeks
2.mPEG-NH2 or mPEG-amide
CH3O-(CH2CH2O)n-CH2CH2-NH2
CH3O-(CH2CH2O)n-CH2CH2CH2-NH2
Purity: ~90%
Time required : about 2 weeks
3. mPEG-SS ( mPEG-succinimidyl succinate)
Purity:>95%。
Time required : about 2 weeks
4. mPEG-SC ( mPEG-succinimidyl carbonate)
purity: >95%.
Time required : about 2 weeks
5. mPEG2-NHS (mPEG2- N-hydroxysuccinimde)
Purity: >95%。
Time required : about 3 weeks
6. mPEG-SPA ( mPEG-succinimidyl propionate)
mPEG-SPA assay: ~95%。
Time required : about 4 weeks
7. mPEG-ALD( mPEG-aldehyde)
purity: ~80%。
8. mPEG-MAL ( mPEG- maleimide)
Purity: ~80%。
Time required : 3 weeks
9. HO-PEG-COOH (α-hydroxyl-PEG-ω- carboxyl)
Time required : 3 weeks
10. mPEG-b-PS (mPEG-block- polystyrene);
Time required : 3 weeks
11. mPEG-b-PI (mPEG-block- polyisoprene);
Time required : 3 weeks
12. mPEG-b-PAN (mPEG-block- polyacrylonitrile);
Time required : 3 weeks
13. mPEG-b-PCL (mPEG-block- poly(ε-caprolactone));
Time required : 1 week
14. mPEG-b-PMMA (mPEG-block- poly(methyl methacrylate));
Time required : 3 weeks
15. HO-PEG-OH (HO-(CH2CH2O)n-CH2CH2OH)
(Disperse(PDI):<1.15), various molecular weight available;
Time required : about 2 weeks
16. HO-PEG-NH2 (α-hydroxyl-PEG-ω- amide)
Time required : about 3 weeks
17. mPEG-carboxyl, various molecular weight available, purity: >95%。
18. mPEG- cyan, various molecular weight available, purity: >95%。
19. mPEG3-COOH 和mPEG3-NHS;
Time required : 3 weeks
20. Triple arm PEG and Tetra arm PEG (All terminal group are hydroxy group.)
Various molecular weight available;
Time required : 3 weeks
21.Hyperbranched poly glycerol hPG (hyperbranched poly(glycerol).
Various molecular weight Hyperbranched poly glycerol PG available
Time required : 3 weeks
Features & Tech Advantages
1. Multiple functional group modified service with a good property and high purity, Mw: 500-80,000, Disperse(PDI) <1.05 (PDI of general market product: 1.60);
2. Simplified manufacture process, low impurity, stable quality;
3. Batch production, cost under control;
4. More than 800 different grades available;
5. Specific grade synthesis acceptable.
1、Single Functional Group PEGs (mPEG-R)
R: |
-CH2NH2;-COOH;-CH2CH2COOH;-EPMAL;-SC;Biotin |
-PPMAL;-SPA;-OCOOPhNO2;-CHO;-VS;-S-S-Pyridine;-Thiol |
|
-CH(OEt)2;-SH;-SS;-SG;-SCM;-OTS;-ButyrALD; -ALD;-AC; -Alkyne;-Azide; -Epoxide;-Hydrazide;-NCO;-NPC;-OPSS;SG;-Silane;-VS |
R1: |
H-;NH2-;COOH-;MAL-;ACLT-;Biotin-;Gluc-;Gala-;AC-;BOC-;NH-;DSPE-;Fluorescein-;OPSS-;Thiol-;ACRL-;FMOC-NH-; |
R2: |
-NH2;-CH2NH2;-CH2CH2CH2NH2;-COOH;-CH2CH2COOH;-CHO;-CH(OEt)2;-NHS;-MAL;SCM;-SC;-Biotin;-Acid;-CM;-SVA;-VA;-Silane; |
R: |
NH2;CH2NH2;CH2CH2COOH;EP-MAL;PP-MAL;NHS;OPSS;AC;ALD;Azide;;EP;GA;Hydrazide;NPC;SH;ACRL;-ButyrALD;-Thiol; |
R: |
-TS;-NP;-GS2;-MAL(C2、C5);-ALD;-PA;CA;-COO-NHS;-CH2CH2CH2-NHCO-(CH2)3-COO-NHS |
X: |
-O-NHS; -NH-CH2CH2-CHO; -NH(CH2)2-NHCO-(CH2)-maleimide |
X: |
-CH2CH2-NHCO-(CH2)3-COO-NHS; -CH2 CH2NH2;--CH2CH2-NHCO-(CH2)2-maleimide |
X: |
-TS; |
Y: |
-COO-C6H5-;-COO-C6H3(CH3)2 |
X: |
-CO-CH2CH2-COO-NHS; -CO-CH2CH2CH2-COO-NHS; -CH2CH2CH2CH2-COO-NHS; -CH2CH2CH2NH2; -CH2CH2NH2; -CH2CH2SH; -(CH2)3-NHCO-CH2CH2-Maleimide; -COO-phenyl-NO2 |
A-b-PEG |
A:PS;PI;PAN;PCL;PMMA;PPO;PGLY;PECH |
mPEG-b-A |
A:PS;PI;PAN;PCL;PMMA;PPO;PGLY;PECH |
A-b-PEG-b-A |
A:PHB; PHB/V;PCL;PLA |
R1-(PEG-b-A)-R2 |
A:PS;PI;PAN;PCL;PMMA;PPO;PGLY;PECH |
R1-(A-b-PEG)-R2 |
A:PHB;PHB/V;PCL;PLA;PPO;PGLY;PECH |
R-(PEG-b-A-b-PEG)-R |
A:PPO;PGLY;PECH |
(PEG-b-A)-R |
A:PS;PI |
R-(PEG-b-A-b-PEG) |
A:PS;PI |
A-b-(PEG)2 |
A:PS;PI |
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