| 訂購貨號 | 產品名稱及規格 |
| 15020 | Cyanine7 NHS ester, 1 mg |
| 25020 | Cyanine7 NHS ester, 5 mg |
| 45020 | Cyanine7 NHS ester, 25 mg |
| 55020 | Cyanine7 NHS ester, 50 mg |
| 65020 | Cyanine7 NHS ester, 100 mg |
胺類活性染料，近紅外熒光染料，Cy7®的改進的類似物。
近紅外熒光素可以被用來利用生物組織的近紅外窗口。在這個光譜區域，高度增強的組織透明度使得活體成像成為可能。該染料可用于制備CY7標記的生物分子來進行后續試驗，如活體研究及藥物開發相關實驗。
Cy7的特殊結構加固了中心聚亞甲基（polymethyne）鏈的穩定性。這種增強的分子結構會使其量子產率較其母結構提供20%，因此它的熒光強度會更大。
該試劑在標記時需要共溶劑有機溶劑。水溶Cy7 NHS ester可以用于蛋白NIR標記。
該試劑在標記時需要共溶劑有機溶劑。水溶Cy7 NHS ester可以用于蛋白NIR標記。
推薦手冊
氨基分子的NHS酯標記(請聯系西寶生物獲取)
Cy® is a trademark of GE Healthcare.
Spectral properties
| Appearance: | green powder |
| Molecular weight: | 682.29 |
| Molecular formula: |
C41H48ClN3O4 |
| Solubility: | soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water |
| Quality control: | NMR 1H (95%) and 13C, TLC, functional testing |
| Storage conditions: | Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Excitation maximum, nm: | 750 |
| Extinction coefficient at excitation maximum, Lmol |
199000 |
| Emission maximum, nm: | 773 |
| Fluorescence quantum yield: | 0.3 |
Product citations
- Zhang, R.; Yang, J.; Radford, D.C.; Fang, Y.; Kope?ek, J. FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate.Macromolecular Bioscience, in press. doi: 10.1002/mabi.201600125
- Pérez-Medina, C.; Abdel-Atti, D.; Tang, J.; Zhao, Y.; Fayad, Z.A.; Lewis, J.S.; Mulder, W.J.M.; Reiner, T. Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy. Nature Communications, 2016, 7, 11838. doi: 10.1038/ncomms11838
- Zhao, Y.; Fay, F.; Hak, S.; Manuel Perez-Aguilar, J.; Sanchez-Gaytan, B.L.; Goode, B.; Duivenvoorden, R.; de Lange Davies, C.; Bjørkøy, A.; Weinstein, H.; Fayad, Z.A.; Pérez-Medina, C.; Mulder, W.J.M. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nature Communications, 2016, 7, 11221. doi: 10.1038/ncomms11221
- Dhande, Y.K.; Wagh, B.S.; Hall, B.C.; Sprouse, D.; Hackett, P.B.; Reineke, T.M. N-Acetylgalactosamine Block-co-Polycations Form Stable Polyplexes with Plasmids and Promote Liver-Targeted Delivery. Biomacromolecules, 2016, 17(3), 830–840. doi:10.1021/acs.biomac.5b01555
- Kim, J.B.; Park, K.; Ryu, Ji.; Lee, J.J.; Lee, M.W.; Cho, H.S.; Nam, H.S.; Park, O.K.; Song, J.W.; Kim, T.S.; Oh, D.J.; Gweon, D.; Oh, W.-Y.; Yoo, H.; Kim, J.W. Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors. Scientific Reports, 2016, 6, 22608. doi: 10.1038/srep22608
- Tolstyka, Z.P.; Phillips, H.; Cortez, M.; Wu, Y.; Ingle, N.; Bell, J.B.; Hackett, P.B.; Reineke, T.M. Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery. ACS Biomaterials Science & Engineering, 2016, 2(1), 43–55. doi: 10.1021/acsbiomaterials.5b00312
- Turcheniuk, K.; Dumych, T.; Bilyy, R.; Turcheniuk, V.; Bouckaert, J.; Vovk, V.; Chopyak, V.; Zaitsev, V.; Mariot, P.; Prevarskaya, N.; Boukherrouba, R.; Szunerits, S. Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites. RSC Advances, 2016, 6(2), 1600–1610. doi: 10.1039/c5ra24662h
- Rudnick-Glick, S.; Corem-Salkmon, E.; Grinberg, I.; Yehuda, R.; Margel, S. Near IR fluorescent conjugated poly(ethylene glycol)bisphosphonate nanoparticles for in vivo bone targeting in a young mouse model. Journal of Nanobiotechnology, 2015, 13(1), 80. doi: 10.1186/s12951-015-0126-0
- Alexander, S.C.; Busby, K.N.; Cole, C.M.; Zhou, C.Y.; Devaraj, N.K. Site-Specific Covalent Labeling of RNA by Enzymatic Transglycosylation. Journal of the American Chemical Society, 2015, 137(40), 12756–12759. doi: 10.1021/jacs.5b07286
- Yu, Q.; Wei, Z.; Shi, J.; Guan, S.; Du, N.; Shen, T.; Tang, H.; Jia, B.; Wang, F.; Gan, Z. Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance. Biomacromolecules, 2015, 16(9), 2645–2655. doi: 10.1021/acs.biomac.5b00460
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