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Cell:利用交互式的、體驗式的現實生活模擬程序來預防疫情爆發
2015年,一組疾病爆發建模專家與教育工作者一起創建了Operation Outbreak,這是一個旨在向高中生和大學生教授應對大流行病基本知識的教育平臺和模擬程序。該程序是開源和免費提供的,旨在用不同的變量(比如R0和傳播模式)模擬疾病爆發,并在真實的人類行為背景下生成數據。它包括一個基于藍牙的應用程序(app),通過記錄手機之間的傳播事件來進行接觸者追蹤。近期,Cell期刊發表一篇標題為“Preventing outbreaks through interactive, experiential real-life simulations”的評論文章,重點介紹了這些細節。[查看]
http://www.baichuan365.com/Article/celllyjhsdtysdxsshmn_1.html
Cell:人膠質母細胞瘤類器官可重現腫瘤特征,并可用于評價藥物和CAR-T細胞的療效
膠質母細胞瘤是最為侵襲性的最為常見的腦癌形式。由患者自身的膠質母細胞瘤培育而成的實驗室大腦類器官可能為如何最好地治療它提供了答案。在一項新的研究中,來自美國賓夕法尼亞大學的研究人員發現膠質母細胞瘤類器官可能可以作為有效的模型來快速地測試個性化治療策略。相關研究結果于2019年10月26日在線發表在Cell期刊上,論文標題為“Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders”。[查看]
http://www.baichuan365.com/Article/cellrjzmxbllqgkzxzlt_1.html
Science:重大進展!首次證實宿主細胞通過減少鎂供應阻止細菌生長
當病原體入侵宿主細胞時,我們的身體會使用各種方法來對抗它們。在一項新的研究中,來自瑞士巴塞爾大學生物中心的研究人員如今能夠證實一種細胞泵如何控制這種入侵的病原體。這種細胞泵導致鎂缺乏,從而限制了細菌性病原體生長。相關研究結果發表在2019年11月22日的Science期刊上,論文標題為“Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation”。[查看]
http://www.baichuan365.com/Article/sciencezdjzsczsszxbt_1.html
Jackson 二抗 有“現”任性 速來訂購
Jackson二抗以種類豐富(物種齊全,標記多樣,應用廣泛)、性價比高、供貨迅捷而深受科研學者和工業客戶的青睞。西寶生物科技(上海)股份有限公司為Jackson ImmunoResearch品牌代理商,公司提供傳統標記二抗(如酶標記,AMCA,FITC,羅丹明,Cy系列等),供應新型染料標記二抗(如Alexa Fluor?,DyLight 405)。[查看]
http://www.baichuan365.com/Article/jacksonekyxrxsldg_1.html
CM<font color='red'>GH</font>:揭秘慢性胰腺炎誘發胰腺癌發生的分子機制
慢性胰腺炎(CP,Chronic pancreatitis)是誘發胰腺導管腺癌(PDAC,pancreatic ductal adenocarcinoma)的易感因素,PDAC是一種最常見且最具致死性的胰腺癌,目前研究人員并不清楚慢性胰腺炎和胰腺導管腺癌之間的關聯。[查看]
http://www.baichuan365.com/Article/cmghjmmxyxyyfyxafsdf_1.html
Jackson DyLight 系列熒光二抗 盡在西寶生物
Jackson ImmunoResearch公司是二抗生產廠商,提供DyLigh?系列熒光標記二抗,DyLigh?系列熒光是一種近年來被廣泛應用的新型熒光染料,主要優點為:具有更好的光譜寬度、更強的熒光強度、更高的光學耐受性(抗淬滅性)、對pH不敏感和分子小而滲透性更好。[查看]
http://www.baichuan365.com/Article/dylighxlyg_1.html
菌群移植輔助腫瘤免疫治療大放異彩
頂級期刊Nature Medicine11月12日在線發表一篇來自德克薩斯大學MD安德森癌癥中心的華人學者Yinghong Wang主導的最新研究,研究報道了用菌群移植(FMT)成功治療了第一例免疫檢查點抑制劑(ICI)相關的結腸炎病例,提示調節腸道菌群的干預方法可用于改善免疫檢查點抑制劑相關結腸炎,有望造福更多癌癥患者。[查看]
http://www.baichuan365.com/Article/jqyzfzzlmyzldfyc_1.html
Jackson ImmunoResearch教你如何選擇二抗
西寶生物科技(上海)股份有限公司為Jackson ImmunoResearch品牌代理商,公司不僅堅持提供傳統標記的二抗(如酶標記,AMCA,FITC,羅丹明,Cy系列等),而且始終與前沿的染料生產商合作,以快的速度供應新型染料標記的二抗(如Alexa Fluor?,DyLight 405)。西寶生物作為二抗Jackson ImmunoResearch的代理商,渠道正規,并備有大量現貨若您對JacksonImmunoResearch產品感興趣,請致電 400-021-8158 了解詳情。[查看]
http://www.baichuan365.com/Article/jacksonimmunoresearc_1.html
JCI Insights:特殊糖類分子能夠降低患II型糖尿病的風險
根據小鼠水平的一項新研究,一種名為海藻糖的天然糖類分子可以阻斷肝臟中的葡萄糖并激活一種能提高胰島素敏感性的基因,從而降低患糖尿病的風險。[查看]
http://www.baichuan365.com/Article/jciinsightststlfzngj_1.html
鑒定出維持干細胞多能性的關鍵性因子BRG1
論文通信作者Nishant Singhal和同事們證實蛋白Brg1在調節參與維持胚胎干細胞多能性的一個基因網絡內的部分基因中發揮著關鍵性作用。這個相同的基因網絡是開發成體細胞重編程方法的靶標。[查看]
http://www.baichuan365.com/Article/jdcwcgxbdnxdgjxyzbrg_1.html
Nature:為何我們的造血干細胞存在于骨髓中?免受紫外線傷害是關鍵!
四十年后,來自美國哈佛大學干細胞與再生生物學系、波士頓兒童醫院干細胞項目和哈佛干細胞研究所的研究人員在一項新的研究中發現了一條有價值的線索:這種造血干細胞壁龕經進化后保護造血干細胞免受陽光中有害紫外線(UV)的傷害。這種對造血干細胞壁龕的新認識將有助人們增強造血干細胞移植的安全性。相關研究結果于2018年6月13日在線發表在Nature期刊上,論文標題為“Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche”。[查看]
http://www.baichuan365.com/Article/naturewhwmdzxgxbczyg_1.html
Cell:體內唾液酸化作用可將有害抗體變為有益抗炎抗體
來自美國麻省總醫院(MGH)和哈佛醫學院的研究人員已經找到一種方法,能將體內有害的自身抗體(autoantibody)直接轉變成抗炎抗體(anti-inflammatory antibody),初步測試顯示,這種技術在自身抗體誘導性疾病小鼠模型中成功減輕了炎癥。[查看]
http://www.baichuan365.com/Article/celltntyshzykjyhktbw_1.html
Sci Rep:科學家開發出可明顯改善反興奮劑檢測的新型技術
近日,來自澳大利亞麥考瑞大學的研究人員通過研究發現了一種新方法,通過追蹤蛋白質的水平來檢測是否一個人服用了人類生長激素(GH),尤其是研究人員利用蛋白質組學技術(研究蛋白質互作)就能夠觀察到當個體服用重組人生長激素后機體哪種蛋白質的水平會發生改變,重組人生長激素是一種人工版本的激素,運動員常常會服用這種激素來增強表現力。[查看]
http://www.baichuan365.com/Article/scirepkxjkfckmxgsfxf_1.html
Acta Neuropathol:科學家鑒別出肺癌患者癌癥腦轉移的新型調節性基因
近日,一項刊登在國際雜志Acta Neuropathologica上的研究報告中,來自麥克馬斯特大學的研究人員通過研究發現,名為SPOCK1和 TWIST2的基因或是肺癌患者機體癌癥腦轉移的新型調節子。 科學家鑒別出肺癌患者癌癥腦轉移的新型調節性基因 圖片來源: McMaster University 研究者Mohini Singh說道,癌癥腦部轉移是一種次級腦瘤,也就意味著其是由逃離原發性腫瘤位點的癌細胞遷移到大腦所引發,比如肺癌、乳腺癌或黑色素瘤等。本文中研究者開始著手研究能夠調節開啟癌癥腦部轉移[查看]
http://www.baichuan365.com/Article/actaneuropatholkxjjb_1.html
Chromeo(TM) 熒光染料 - 高效生物熒光標記
Chromeo熒光染料 -- Chromeo 488,Chromeo 494,Chromeo 505,Chromeo 546和Chromeo642– 是發色明亮的熒光標記染料,可替代Alexa Fluor*,Dylight *和CY*染料。Chromeo熒光染料,發光性能優異、斯托克斯位移寬、對光漂白和pH穩定、細胞毒性低。此外,與大多數激發光源匹配,包括二極管激光器,LED,鎢燈和氙氣弧燈。為了便于標記,提供一系列化學結構的Chromeo染料,以及二抗結合染料。[查看]
http://www.baichuan365.com/Article/chromeo_fluorescent_dyes_1.html
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