免疫檢查點活性蛋白及相關(guān)產(chǎn)品 CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

來源：作者：人氣：-發(fā)表時間：2023-11-15 09:04:00【大中小】

免疫檢查點活性蛋白及相關(guān)產(chǎn)品

CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3

◆活性免疫檢測點蛋白

B7-H4 (human):Fc (human) (rec.)	CHI-HF-210B7H4
B7-H4 (mouse):Fc (mouse) (rec.)	CHI-MF-110B7H4
CTLA-4 (human):Fc (human) (rec.)	CHI-HF-210A4
CTLA-4 (human):Fc (human) (rec.) (non-lytic)	CHI-HF-220A4
CTLA-4 (human):Fc (mouse) (rec.)	CHI-HF-211A4
CTLA-4 (mouse):Fc (mouse) (rec.)	CHI-MF-110A4
CTLA-4 (mouse):Fc (mouse) (rec.) (non-lytic)	CHI-MF-120A4
PD-1 (human):Fc (human) (rec.)	CHI-HF-210PD1
PD-1 (human):Fc (human) (rec.) (non-lytic)	CHI-HF-220PD1
PD-1 (mouse):Fc (mouse) (rec.)	CHI-MF-110PD1
PD-L1/B7-H1 (human):Fc (human) (rec.)	CHI-HF-210PDL1
PD-L1/B7-H1 (human):Fc (human) (rec.) (non-lytic)	CHI-HF-220PDL1
PD-L1/B7-H1 (mouse):Fc (mouse) (rec.)	CHI-MF-110PDL1
PD-L1/B7-H1 (mouse):Fc (mouse) (rec.) (non-lytic)	CHI-MF-120PDL1
PD-L2 (human):Fc (human) (rec.)	CHI-HF-210PDL2
PD-L2 (human):Fc (human) (rec.) (non-lytic)	CHI-HF-220PDL2
PD-L2 (mouse):Fc (mouse) (rec.)	CHI-MF-110PDL2

◆IDO1酶&主要抑制劑

IDO1 (human) Enzyme+Inhibitor Set	AG-44B-0006
IDO1 (human) (rec.) (His) (highly active)	AG-40B-0161

MMG-0358 Potent Triazole IDO1 Inhibitor AG-CR1-3630

IC50值，mIDO1細(xì)胞檢測是2 nM，hIDO1細(xì)胞檢測是80 nM，hIDO1（pH 6.5）酶活檢測是330 nM，hIDO1（pH7.4）的酶活檢測是71 nM。體內(nèi)有活性。

參考文獻

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. , 55, 5270 (2012)

◆腫瘤免疫治療的LAG-3

功能性封閉抗體
LAG-3 (human), mAb (blocking) (17B4)	AG-20B-0012
LAG-3 (human), mAb (blocking) (17B4) (preservative free)	AG-20B-0012PF
LAG-3, mAb (blocking) (11E3)	AG-20B-0011
LAG-3, mAb (blocking) (11E3) (preservative free)	AG-20B-0011PF
生物活性蛋白
LAG-3 (human):Fc (human) (rec.)	AG-40B-0031
LAG-3 (mouse):Fc (mouse) (rec.)	AG-40B-0039

◆T-細(xì)胞免疫球蛋白和粘蛋白結(jié)構(gòu)域

Tim-3 (human):Fc (human) (rec.)	CHI-HF-210T3
Tim-3 (mouse):Fc (mouse) (rec.)	CHI-MF-110T3

◆CD1d配體抗腫瘤佐劑

α-Galactosylceramide

Potent NKT Cell stimulator

強有效NKT 激活劑

AG-CN2-0013

在人類和小鼠NKT細(xì)胞里MHC-I蛋白和CD1d分子脂質(zhì)結(jié)合的特異性配體。

參考文獻

LIT: Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine: F. Gableh, et al.; J. Biomed. Sci., 23, 16 (2016)

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